Serializer circuitry for high-speed serial data transmitter circuitry on a programmable logic device (“PLD”) or the like includes circuitry for converting parallel data having any of several data widths to serial data. The circuitry can also operate at any frequency in a wide range of frequencies, and can make use of reference clock signals having any of several relationships to the parallel data rate and/or the serial data rate. The circuitry is configurable/re-configurable in various respects, at least some of which configuration/re-configuration can be dynamically controlled (i.e., during user-mode operation of the PLD).