A driving method of a display panel includes the following steps: driving the display panel to display a first image frame and providing display data of a second image frame, and each of the first and the second image frames has a first area and a second area for respectively displaying two different display contents, the positions of the two corresponding first areas overlap, and the positions of the two corresponding second areas overlap; determining whether display content differences exist between the two corresponding first areas, and determining whether display content differences exist between the two corresponding second areas, and driving the area where display content differences exist in the two areas of the first image frame to display a first-color display content when display content differences exist between the two corresponding first areas or the two corresponding second areas. Furthermore, a corresponding electrophoresis display apparatus is also provided.