Systems and methods are described for gesture-based control using three-dimensional information extracted over an extended depth of field. The system comprises a plurality of optical detectors coupled to at least one processor. The optical detectors image a body. At least two optical detectors of the plurality of optical detectors comprise wavefront coding cameras. The processor automatically detects a gesture of the body, wherein the gesture comprises an instantaneous state of the body. The detecting comprises aggregating gesture data of the gesture at an instant in time. The gesture data includes focus-resolved data of the body within a depth of field of the imaging system. The processor translates the gesture to a gesture signal, and uses the gesture signal to control a component coupled to the processor.