Invention Grant
- Patent Title: Adoptive cell therapy with young T cells
- Patent Title (中): 采用年轻T细胞进行细胞疗法
-
Application No.: US13742541Application Date: 2013-01-16
-
Publication No.: US09074185B2Publication Date: 2015-07-07
- Inventor: Mark E. Dudley , Steven A. Rosenberg
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K35/12 ; A61K38/00 ; C12N5/0783 ; A61K31/675 ; A61K31/7076 ; A61K35/17 ; A61K35/26 ; A61K38/20 ; A61K39/00
Abstract:
The invention provides a method of promoting regression of a cancer in a mammal comprising (i) culturing autologous T cells; (ii) expanding the cultured T cells; (iii) administering to the mammal nonmyeloablative lymphodepleting chemotherapy; and (iv) after administering nonmyeloablative lymphodepleting chemotherapy, administering to the mammal the expanded T cells, wherein the T cells administered to the mammal are about 19 to about 35 days old and have not been screened for specific tumor reactivity, whereupon the regression of the cancer in the mammal is promoted.
Public/Granted literature
- US20140030806A1 ADOPTIVE CELL THERAPY WITH YOUNG T CELLS Public/Granted day:2014-01-30
Information query
