Invention Grant
US09073975B2 Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion
有权
循环肽，它们的制备及其作为血小板粘附抑制剂的用途
- Patent Title: Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion
- Patent Title (中): 循环肽，它们的制备及其作为血小板粘附抑制剂的用途
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Application No.: US13818444Application Date: 2011-07-27
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Publication No.: US09073975B2Publication Date: 2015-07-07
- Inventor: Otmar Klingler , Horst Blum , Andreas Lindenschmidt , Hans Matter
- Applicant: Otmar Klingler , Horst Blum , Andreas Lindenschmidt , Hans Matter
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Agent Sabine Venne-Dunker
- Priority: EP10305842 20100729
- International Application: PCT/EP2011/062917 WO 20110727
- International Announcement: WO2012/013709 WO 20120202
- Main IPC: C07K7/64
- IPC: C07K7/64 ; C07K7/06 ; C07K7/56 ; A61K38/00
Abstract:
The present invention relates to compounds of the Formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, X1, X2, X3 and X4 have the meanings indicated in the claims, and which are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb), and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases. The invention furthermore relates to processes for the preparation of compounds of the Formula (I), their use, in particular as active ingredients in medicaments, and pharmaceutical compositions comprising them.
Public/Granted literature
- US20140011734A1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION Public/Granted day:2014-01-09
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