Invention Grant
- Patent Title: RGD-containing cyclic peptides
- Patent Title (中): 含RGD的环肽
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Application No.: US13517039Application Date: 2010-12-16
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Publication No.: US09073974B2Publication Date: 2015-07-07
- Inventor: Kit S. Lam , Yan Wang , Wenwu Xiao
- Applicant: Kit S. Lam , Yan Wang , Wenwu Xiao
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2010/060731 WO 20101216
- International Announcement: WO2011/079015 WO 20110630
- Main IPC: C07K7/50
- IPC: C07K7/50 ; A61K38/12 ; C07K7/64 ; C07K14/78 ; A61K38/00
Abstract:
The present invention is drawn to cyclic RGD peptides linked via a disulfide bond, where the terminal cysteines are preferably in the D configuration. These peptides target αvβ3 integrin on tumor cells and neovasculatures and function as targeting agents for tumor diagnostic imaging and therapy. Compared with the commonly used RGD ligands, compounds of the present invention have improved targeting efficacy and lower nonspecific binding to normal organs. Moreover, the compounds of the present invention can be functionalized to conjugate imaging payload without decreasing binding strength.
Public/Granted literature
- US20130172270A1 RGD-CONTAINING CYCLIC PEPTIDES Public/Granted day:2013-07-04
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