Invention Grant
US09073935B2 Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
有权
取代的苄基螺吲哚啉-2-酮类似物作为毒蕈碱性乙酰胆碱受体M1的正变构调节剂
- Patent Title: Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
- Patent Title (中): 取代的苄基螺吲哚啉-2-酮类似物作为毒蕈碱性乙酰胆碱受体M1的正变构调节剂
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Application No.: US13674016Application Date: 2012-11-10
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Publication No.: US09073935B2Publication Date: 2015-07-07
- Inventor: Craig W. Lindsley , P. Jeffrey Conn , Michael R. Wood , Corey R. Hopkins , Bruce J. Melancon , Michael S. Poslusney
- Applicant: VANDERBILT UNIVERSITY
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: C07D487/10
- IPC: C07D487/10 ; C07D471/10 ; C07D491/113 ; C07D491/107
Abstract:
In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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