Invention Grant
- Patent Title: Pyrazole derivatives
- Patent Title (中): 吡唑衍生物
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Application No.: US13485969Application Date: 2012-06-01
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Publication No.: US09073911B2Publication Date: 2015-07-07
- Inventor: Guido Galley , Cedric Ghellamallah , Roger Norcross , Philippe Pflieger
- Applicant: Guido Galley , Cedric Ghellamallah , Roger Norcross , Philippe Pflieger
- Applicant Address: US NJ Nutley
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- Priority: EP11169217 20110609
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D413/14

Abstract:
The invention relates to compounds of formula IA and IB wherein R1, R2, R3, R4 and Z are as defined herein or to a pharmaceutically suitable acid addition salt thereof. Compounds of formulas IA and IB have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
Public/Granted literature
- US20120316172A1 PYRAZOLE DERIVATIVES Public/Granted day:2012-12-13
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