A non-stick medical tubing is provided. The non-stick tubing comprises a plastic resin mixture including a first plastic resin component and a second plastic resin component, the second plastic resin comprising a medical grade amide compound, the plastic resin mixture extruded by an extruding apparatus as a mono-layered tube such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.