Invention Grant
US09072788B2 Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
有权
NH-酸性化合物的前药：酯，碳酸盐，氨基甲酸酯和膦酸酯衍生物
- Patent Title: Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
- Patent Title (中): NH-酸性化合物的前药：酯，碳酸盐，氨基甲酸酯和膦酸酯衍生物
-
Application No.: US14034918Application Date: 2013-09-24
-
Publication No.: US09072788B2Publication Date: 2015-07-07
- Inventor: Laura Cook Blumberg , Julius F. Remenar , Orn Almarsson , Tarek A. Zeidan
- Applicant: Alkermes Pharma Ireland Limited
- Applicant Address: IE Dublin
- Assignee: Alkermes Pharma Ireland Limited
- Current Assignee: Alkermes Pharma Ireland Limited
- Current Assignee Address: IE Dublin
- Agency: Elmore Patent Law Group, P.C.
- Agent Carolyn S. Elmore; Roy P. Issac
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K47/48 ; C07D215/227
Abstract:
The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
Public/Granted literature
- US20140094472A1 PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES Public/Granted day:2014-04-03
Information query
IPC分类:
