Invention Grant
US09072766B2 Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
有权
通过抑制烟酰胺N-甲基转移酶（NNMT）治疗肥胖的方法
- Patent Title: Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
- Patent Title (中): 通过抑制烟酰胺N-甲基转移酶（NNMT）治疗肥胖的方法
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Application No.: US13885284Application Date: 2011-11-18
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Publication No.: US09072766B2Publication Date: 2015-07-07
- Inventor: Barbara B. Kahn , Qin Yang , Daniel Kraus
- Applicant: Barbara B. Kahn , Qin Yang , Daniel Kraus
- Applicant Address: US MA Boston
- Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2011/061397 WO 20111118
- International Announcement: WO2012/068463 WO 20120524
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/712 ; C12N9/10 ; A61K39/395
Abstract:
The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders.
Public/Granted literature
- US20130243790A1 Methods Of Treating Obesity By Inhibiting Nicotinamide N-Methyl Transferase (NNMT) Public/Granted day:2013-09-19
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