Invention Grant
US09072737B2 tPA mutant in the treatment of acute brain injury and neurodegenerative disorders
有权
tPA突变体治疗急性脑损伤和神经退行性疾病
- Patent Title: tPA mutant in the treatment of acute brain injury and neurodegenerative disorders
- Patent Title (中): tPA突变体治疗急性脑损伤和神经退行性疾病
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Application No.: US12922551Application Date: 2009-03-16
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Publication No.: US09072737B2Publication Date: 2015-07-07
- Inventor: Abd Higazi , Nuha Hijazi
- Applicant: Abd Higazi , Nuha Hijazi
- Applicant Address: IL Jerusalem
- Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
- Current Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
- Current Assignee Address: IL Jerusalem
- Agency: Browdy and Neimark, PLLC
- Priority: IL190184 20080316
- International Application: PCT/IL2009/000300 WO 20090316
- International Announcement: WO2009/116035 WO 20090924
- Main IPC: A61K38/49
- IPC: A61K38/49 ; A61K38/26 ; A61K38/28 ; A61K38/45 ; C12N9/72
Abstract:
The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.
Public/Granted literature
- US20110008313A1 tPA MUTANT IN THE TREATMENT OF ACUTE BRAIN INJURY AND NEURODEGENERATIVE DISORDERS Public/Granted day:2011-01-13
Information query
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