Invention Grant
- Patent Title: Indication for use of niacin (nicotinic acid) for treatment and reversal of fatty liver disease
- Patent Title (中): 使用烟酸（烟酸）治疗和逆转脂肪肝病的适应症
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Application No.: US13988972Application Date: 2011-11-22
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Publication No.: US09072732B2Publication Date: 2015-07-07
- Inventor: Moti L. Kashyap , Vaijinath S. Kamanna , Shobha V. Kamanna
- Applicant: Moti L. Kashyap , Vaijinath S. Kamanna , Shobha V. Kamanna
- Applicant Address: US CA Oakland US CA Long Beach
- Assignee: The Regents of the University of California,Veterans Affairs Health Care System
- Current Assignee: The Regents of the University of California,Veterans Affairs Health Care System
- Current Assignee Address: US CA Oakland US CA Long Beach
- Agency: Berliner & Associates
- International Application: PCT/US2011/061931 WO 20111122
- International Announcement: WO2012/071459 WO 20120531
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/455 ; A61K45/06 ; C07D213/80
Abstract:
Niacin prevents and/or reverses the development of experimental hepatic steatosis, deposition of triglycerides in liver and serum of individuals, deposition of total cholesterol in liver and serum in individuals, and inhibit liver lipid peroxidation and oxidative stress in individuals at risk of developing fatty liver disease or NAFLD. In cultured human hepatocytes, niacin inhibits alcohol-induced fat accumulation.
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