Invention Grant
- Patent Title: Recombinant factor VIII having increased stability
- Patent Title (中): 具有增加的稳定性的重组因子VIII
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Application No.: US13691474Application Date: 2012-11-30
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Publication No.: US09072722B2Publication Date: 2015-07-07
- Inventor: Philip J. Fay , Hironao Wakabayashi
- Applicant: University of Rochester
- Applicant Address: US NY Rochester
- Assignee: University of Rochester
- Current Assignee: University of Rochester
- Current Assignee Address: US NY Rochester
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: A61K38/37
- IPC: A61K38/37 ; C07K14/755
Abstract:
The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.
Public/Granted literature
- US20130085110A1 RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY Public/Granted day:2013-04-04
Information query
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