Disclosed in the present invention are a method and apparatus for serial device registration. Said method comprises: a first serial device establishes connection with a second serial device; the first serial device reports the device attribute information of the first serial device to the second serial device, so as to initiate the process of registering the first serial device in the second device; in the registration process, after receiving the request of asking for signature certificate from the second serial device, the first serial device sends a first signature certificate to the second serial device; computing the received first challenge code returned from the second serial device, and obtaining a first signature value; sending the first signature value to the second serial device, so as to authenticate the first signature value by the second serial device and return the authentication result to the first serial device; after the authentication, the first serial device accomplishes the registration in the second serial device. The present invention solves the problem of lacking security authentication mechanism at the time of registering, thus improving communication security.