A system, in certain embodiments, includes a casing head and a tubing hanger disposed within the casing head and supported by a first retaining feature of the casing head. The tubing hanger is configured to support a tubing string. The system also includes a guide string hanger disposed within the casing head and supported by a second retaining feature of the casing head independent of the first retaining feature. The guide string hanger is configured to support a guide string.