Invention Grant
US09051561B2 Asparaginase and treating diseases associated with asparagine dependence
有权
天冬酰胺酶和治疗与天冬酰胺依赖相关的疾病
- Patent Title: Asparaginase and treating diseases associated with asparagine dependence
- Patent Title (中): 天冬酰胺酶和治疗与天冬酰胺依赖相关的疾病
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Application No.: US14348637Application Date: 2012-10-09
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Publication No.: US09051561B2Publication Date: 2015-06-09
- Inventor: Donald Durden
- Applicant: Children's Hospital Los Angeles
- Applicant Address: US CA Los Angeles
- Assignee: Children's Hospital Los Angeles
- Current Assignee: Children's Hospital Los Angeles
- Current Assignee Address: US CA Los Angeles
- Agency: Canady + Lortz LLP
- Agent Suzannah K. Sunby, Esq.
- International Application: PCT/US2012/059379 WO 20121009
- International Announcement: WO2013/055699 WO 20130418
- Main IPC: A61K38/48
- IPC: A61K38/48 ; A61K38/46 ; C12N9/82 ; A61K38/50
Abstract:
Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to W. succinogenes asparaginase, but have an amino acid residue other than proline at amino acid position 121. The polypeptides exhibit higher kinetic rates of asparaginase activity to glutaminase activity as compared to W. succinogenes asparaginase and Elspar®, an E. coli asparaginase.
Public/Granted literature
- US20140248255A1 Novel Asparaginase and Treating Diseases Associated With Asparagine Dependence Public/Granted day:2014-09-04
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