Invention Grant
- Patent Title: Metalloinsertor complexes targeted to DNA mismatches
- Patent Title (中): 金属支架复合物靶向DNA错配
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Application No.: US13917447Application Date: 2013-06-13
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Publication No.: US09051345B2Publication Date: 2015-06-09
- Inventor: Jacqueline K. Barton , Alexis Komor , Curtis J. Schneider , Alyson Weidmann , Russell Ernst
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Christie, Parker & Hale, LLP
- Main IPC: C07F15/00
- IPC: C07F15/00 ; C07D241/36
Abstract:
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the inventive metalloinsertor complexes.
Public/Granted literature
- US20130345189A1 METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES Public/Granted day:2013-12-26
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