Invention Grant
US09051337B2 Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamides
有权
取代的10-羟基-9,11-二氧代-2,3,4a，5,9,11,13,13a-八氢-1h吡啶并[1,2-a]吡咯并[1'，2'：3,4 ]咪唑并[1,2-d]吡嗪-8-甲酰胺
![Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamides](/docs/US/2015-06-09/US09051337B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamides
- Patent Title (中): 取代的10-羟基-9,11-二氧代-2,3,4a，5,9,11,13,13a-八氢-1h吡啶并[1,2-a]吡咯并[1'，2'：3,4 ]咪唑并[1,2-d]吡嗪-8-甲酰胺
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Application No.: US14211364Application Date: 2014-03-14
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Publication No.: US09051337B2Publication Date: 2015-06-09
- Inventor: Brian A. Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- Applicant: Shionogi & Co., Ltd. , ViiV Healthcare Company
- Applicant Address: JP Osaka US NC Research Triangle Park
- Assignee: Shionogi & Co., Ltd.,ViiV Healthcare Company
- Current Assignee: Shionogi & Co., Ltd.,ViiV Healthcare Company
- Current Assignee Address: JP Osaka US NC Research Triangle Park
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-131161 20050428; JP2005-312076 20051027
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D241/38 ; C07D498/22 ; C07D471/04 ; C07D471/14 ; C07D498/04 ; C07D471/22 ; C07D498/14 ; C07D498/20
![Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamides](/abs-image/US/2015/06/09/US09051337B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
Public/Granted literature
- US20140200209A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY Public/Granted day:2014-07-17
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