Invention Grant
US09051329B2 Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
有权
可用作二肽基肽酶-IV抑制剂的三环杂环
- Patent Title: Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
- Patent Title (中): 可用作二肽基肽酶-IV抑制剂的三环杂环
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Application No.: US14125116Application Date: 2012-07-02
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Publication No.: US09051329B2Publication Date: 2015-06-09
- Inventor: Wen-Lian Wu
- Applicant: Wen-Lian Wu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Catherine D. Fitch
- International Application: PCT/US2012/045182 WO 20120702
- International Announcement: WO2013/006526 WO 20130110
- Main IPC: A61K31/505
- IPC: A61K31/505 ; C07D491/00 ; C07D487/14 ; A61K31/519 ; A61K31/529
Abstract:
The present invention is directed to novel tricyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US20140113920A1 TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS Public/Granted day:2014-04-24
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