Invention Grant
- Patent Title: Guanidine compound
- Patent Title (中): 胍化合物
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Application No.: US14099131Application Date: 2013-12-06
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Publication No.: US09051283B2Publication Date: 2015-06-09
- Inventor: Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Hiroyoshi Yamada , Hisashi Mihara , Norio Seki
- Applicant: Astellas Pharma Inc.
- Applicant Address: JP Tokyo
- Assignee: ASTELLAS PHARMA INC.
- Current Assignee: ASTELLAS PHARMA INC.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2011-056031 20110315
- Main IPC: C07D401/12
- IPC: C07D401/12 ; A61K31/4412 ; C07D267/10 ; C07D205/04 ; C07D211/60 ; C07D211/78 ; C07D213/38 ; C07D213/64 ; C07D213/74 ; C07D217/06 ; C07D217/22 ; C07D237/20 ; C07D239/26 ; C07D239/42 ; C07D241/20 ; C07D277/42 ; C07D277/46 ; C07D277/56 ; C07D295/06 ; C07D295/08 ; C07D295/18 ; C07D295/20 ; C07D309/08 ; C07D309/14 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; C07D413/14 ; C07D239/48

Abstract:
[Problem]The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases.[Means for Solution]The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient.
Public/Granted literature
- US20140100210A1 GUANIDINE COMPOUND Public/Granted day:2014-04-10
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