Invention Grant
- Patent Title: Piperazinyl cyclohexane compounds as GPR38 agonists
- Patent Title (中): 哌嗪基环己烷化合物作为GPR38激动剂
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Application No.: US14142479Application Date: 2013-12-27
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Publication No.: US09051255B2Publication Date: 2015-06-09
- Inventor: Narihiro Toda , Rieko Takano , Takeshi Shida , Takahiro Katagiri , Mitsuhiro Iwamoto , Shinji Ashida , Mami Yamazaki
- Applicant: Daiichi Sankyo Company, Limited
- Applicant Address: JP Chuo-ku
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Chuo-ku
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Priority: JP2010-215403 20100927
- Main IPC: A61K31/495
- IPC: A61K31/495 ; A61K31/496 ; C07D241/04 ; C07D401/12 ; C07D413/12 ; C07C59/255 ; C07D213/64 ; C07D295/135 ; C07D403/12 ; C07D213/643 ; C07D295/155

Abstract:
To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom or a C1-C3 alkyl group; R3 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; R4 represents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, —O—, —NH—, —N(C1-C3 alkyl)-, —C(═O)—, —S—, —S(O)—, —S(O2)—, or a single bond.
Public/Granted literature
- US20140221391A1 CYCLOHEXANE DERIVATIVE COMPOUND Public/Granted day:2014-08-07
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