A mattress retention system for adjustable beds employs a tension web attached to a top surface of an element of an articulating support structure. The tension web is inset from a longitudinal edge and lateral edges of the articulating support structure element and incorporates a first fastener moiety on an extending edge. A mating element is attached to the bottom surface of a mattress adjacent an edge to be restrained. The mating element incorporates a second fastener moiety for operable connection to the first fastener moiety and includes a web section having a first edge attached to the bottom surface of the mattress and a second edge carrying the second fastener moiety for flexibility in attaching the fastener moieties.