A cooperative multi-user multiple input, multiple output (MIMO) system coordinates spatially distributed network transceiver nodes for communicating with wireless client devices. A MIMO processor pre-codes data for transmission from the network transceiver nodes, wherein the pre-coding comprises subspace coding derived from channel measurements between the network transceiver nodes and the wireless client devices. A network controller coordinates the network transceiver nodes to transmit simultaneous non-interfering channels within a common frequency to the wireless client devices such that each client device receives a subspace-coded transmission from each of the network transceiver nodes. The client devices and/or the network transceiver nodes may be selected based on channel state information and/or measured channel quality.