A power injector (40) includes a movable ram (74) operable to interface with and move a plunger (90a/b) of a syringe (86a/b). The power injector (40) may be operable to automatically determine a proper home position for a particular type of the syringe (86a/b) to be used in a fluid injection sequence. The power injector (40) may also include a ram homing logic (182) operable to automatically move the ram (74) to the home position after the injection sequence. Such automatic homing of the ram (74) may, for example, be initiated by an end of the injection sequence in preparation for another injection sequence, by opening of a faceplate (102a/b), by a user input, or by any combination thereof.