Invention Grant
US09044520B2 Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling
有权
化合物累积在炎症部位,含有标记状态的化合物的诊断剂及其前体化合物进行标记
- Patent Title: Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling
- Patent Title (中): 化合物累积在炎症部位,含有标记状态的化合物的诊断剂及其前体化合物进行标记
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Application No.: US13434722Application Date: 2012-03-29
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Publication No.: US09044520B2Publication Date: 2015-06-02
- Inventor: Hideo Saji , Hiroyuki Kimura , Masahiro Ono , Ikuya Seki
- Applicant: Hideo Saji , Hiroyuki Kimura , Masahiro Ono , Ikuya Seki
- Applicant Address: JP Tokyo JP Kyoto
- Assignee: Nihon Medi-Physics Co., Ltd.,Kyoto University
- Current Assignee: Nihon Medi-Physics Co., Ltd.,Kyoto University
- Current Assignee Address: JP Tokyo JP Kyoto
- Agency: Baker & Hostetler LLP
- Priority: JP2011-090476 20110330
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; A61K51/08

Abstract:
Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2 (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.
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