The present invention relates to an image signal processing circuit, an image capture device, and image signal processing method, and a program capable of reading special information, such as a bar code, using normal lenses with high precision without needing dedicated EDOF lenses and signal processing circuits. The image signal processing circuit has a processing circuit 131 which performs image processing using one color signal (B) having resolution on a near point side from among a plurality of color signals, and an enhancement processing unit 132 which performs enhancement processing by applying an inverse function of a point spread function (PSF) to a signal subjected to the image processing using the one color signal by the processing circuit.