Systems and methods for content selection and processing in an information system are described herein. In one example, a content suggestion engine operates to select, suggest, or recommend content to human users. The selection of content may be suited to a goal or set of goals set by a human user (for example, content recommendations used to assist the human user with achieving a personal health goal). The content suggestion engine may evaluate information to help determine the appropriateness of the content suggestions, considering factors such as a psychological profile, medical conditions, lifestyle, demographics, and goals. The content may be further filtered and weighted to select a subset of content and suggested actions most relevant to the human user.