Remote tamper detection. At least some of the example embodiments are methods including: receiving Global Positioning System (GPS) signals indicative of a location, the receiving by a first device coupled to an asset; periodically sending a signal of operability between the first device and a second device, the second device coupled to the asset, and the second device configured to selectively disable the asset; determining that receipt of the signal of operability has ceased; and then issuing an indication of the location of the first device responsive to the determining that receipt of the signal of operability has ceased, the issuing from the first device by a wireless transmission to a remote operations center.