Invention Grant
US09034840B2 Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers
有权
靶向TCTP的核酸用于治疗化学或激素抵抗性癌症
- Patent Title: Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers
- Patent Title (中): 靶向TCTP的核酸用于治疗化学或激素抵抗性癌症
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Application No.: US13994862Application Date: 2011-12-19
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Publication No.: US09034840B2Publication Date: 2015-05-19
- Inventor: Palma Rocchi , Virginie Baylot , Julie Acunzo , Claudia Andrieu , Maria Katsogiannou
- Applicant: Palma Rocchi , Virginie Baylot , Julie Acunzo , Claudia Andrieu , Maria Katsogiannou
- Applicant Address: FR Paris FR Marseilles
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Universite de la Mediterrance Aix-Marseille II
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Universite de la Mediterrance Aix-Marseille II
- Current Assignee Address: FR Paris FR Marseilles
- Agency: Whitham, Curtis, Christofferson & Cook, P.C.
- Priority: EP10306447 20101217
- International Application: PCT/EP2011/073186 WO 20111219
- International Announcement: WO2012/080509 WO 20120621
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K45/06 ; C12N15/113 ; A61K31/337 ; A61K31/713 ; A61K39/395 ; A61N5/10
Abstract:
The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.
Public/Granted literature
- US20130266572A1 NUCLEIC ACIDS TARGETING TCTP FOR USE IN THE TREATMENT OF CHEMO-OR HORMONE- RESISTANT CANCERS Public/Granted day:2013-10-10
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