Invention Grant
US09034626B2 Methods of preparing tissues for xenotransplantation using alpha-galactosidases
有权
使用α-半乳糖苷酶制备异种移植组织的方法
- Patent Title: Methods of preparing tissues for xenotransplantation using alpha-galactosidases
- Patent Title (中): 使用α-半乳糖苷酶制备异种移植组织的方法
-
Application No.: US14507010Application Date: 2014-10-06
-
Publication No.: US09034626B2Publication Date: 2015-05-19
- Inventor: Qiyong Peter Liu , Henrik Clausen
- Applicant: Velico Medical, Inc.
- Applicant Address: US MA Beverly
- Assignee: Velico Medical, Inc.
- Current Assignee: Velico Medical, Inc.
- Current Assignee Address: US MA Beverly
- Agency: AGG Intellectual Property Law
- Agent Antoinette G. Giugliano
- Main IPC: C12Q1/34
- IPC: C12Q1/34 ; C12N9/40 ; A61K35/32 ; C12N5/077
Abstract:
This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of α3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.
Public/Granted literature
- US20150087061A1 Methods of Preparing Tissues for Xenotransplantation Using Alpha-galactosidases Public/Granted day:2015-03-26
Information query
