Invention Grant
US09034576B2 Systems and methods for measuring translation of target proteins in cells
有权
用于测量细胞中靶蛋白翻译的系统和方法
- Patent Title: Systems and methods for measuring translation of target proteins in cells
- Patent Title (中): 用于测量细胞中靶蛋白翻译的系统和方法
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Application No.: US13497273Application Date: 2010-09-21
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Publication No.: US09034576B2Publication Date: 2015-05-19
- Inventor: Zeev Smilansky , Barry S. Cooperman , Yale E. Goodman
- Applicant: Zeev Smilansky , Barry S. Cooperman , Yale E. Goodman
- Applicant Address: US NJ Bernardsville
- Assignee: ANIMA CELL METROLOGY INC.
- Current Assignee: ANIMA CELL METROLOGY INC.
- Current Assignee Address: US NJ Bernardsville
- Agency: Roach Brown McCarthy & Gruber, P.C.
- Agent Kevin D. McCarthy
- International Application: PCT/IL2010/000792 WO 20100921
- International Announcement: WO2011/036666 WO 20110331
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/50 ; G01N33/542
Abstract:
The present invention relates to systems and methods for measuring the rate of translation of a target protein in cells, which are based on the detection of translation of one or more predetermined codon pairs during synthesis of the target protein. The detection is provided by a FRET signal emitted from labeled tRNA molecules which are juxtaposed during synthesis of the protein.
Public/Granted literature
- US20120183957A1 SYSTEMS AND METHODS FOR MEASURING TRANSLATION OF TARGET PROTEINS IN CELLS Public/Granted day:2012-07-19
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