Invention Grant
- Patent Title: Attenuated human parainfluenza virus, methods and uses thereof
- Patent Title (中): 减毒人副流感病毒,其方法和用途
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Application No.: US13501447Application Date: 2006-01-10
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Publication No.: US09034343B2Publication Date: 2015-05-19
- Inventor: Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins , Sheila Nolan
- Applicant: Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins , Sheila Nolan
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- International Application: PCT/US2006/000666 WO 20060110
- International Announcement: WO2007/120120 WO 20071025
- Main IPC: A61K39/155
- IPC: A61K39/155 ; C12N15/86 ; C12N7/04 ; C12N7/01 ; C07K14/005 ; C12N7/00 ; A61K39/00

Abstract:
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
Public/Granted literature
- US20130052718A1 ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF Public/Granted day:2013-02-28
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