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US09034343B2 Attenuated human parainfluenza virus, methods and uses thereof 有权
减毒人副流感病毒,其方法和用途

Attenuated human parainfluenza virus, methods and uses thereof
Abstract:
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
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