The present invention relates to a self-service cleanroom suit borrowing/returning system and a self-service borrowing/returning method thereof. The self-service cleanroom suit borrowing/returning system includes an automatic cleanroom suit management system backside servo, a borrowing/returning terminal, and a self-service borrowing/returning cleanroom suit machine. The borrowing/returning terminal is connected, via data communication network, to the automatic cleanroom suit management system backside servo, whereby a user uses the borrowing/returning terminal to enter information required for self-service borrowing/returning of cleanroom suit to the automatic cleanroom suit management system backside servo. The self-service borrowing/returning cleanroom suit machine includes a cleanroom suit returning box for a user to deposit a cleanroom suit and a cleanroom suit borrowing box for a user to retrieve a cleanroom suit, both of which are associated with the automatic cleanroom suit management system backside servo.