Techniques are described herein that use sensors (e.g., microphones) for noise reduction in a mobile communication device. For example, one technique enables a first sensor that is initially configured to be a speech sensor to be used as a noise reference sensor. This technique also enables a second sensor that is initially configured to be a noise reference sensor to be used as a speech sensor. Another technique enables a primary sensor and/or a secondary sensor in a handset of a mobile communication device to be used as a speech sensor while a sensor in a headset of the mobile communication device is used as a noise reference sensor, or vice versa. In yet another technique, a secondary sensor in a mobile communication device is configured to be a directional sensor.