A mechanism for reconstructing sub-images based on measurement data acquired by an imaging system including an array of light modulating elements and an array of photodetectors. Each sub-image is reconstructed based on samples from a respective photodetector and a respective set of measurement patterns defined on a respective virtual sub-region on the modulating array. Each virtual sub-region is configured to include at least the light modulating elements that are able to send a non-trivial amount of light to the respective photodetector during a pattern application period. The virtual sub-regions overlap because many light modulating elements are capable of sending light to more than one photodetector. Whenever a measurement pattern of one virtual sub-region overlaps the measurement pattern of a neighboring virtual sub-region, the two measurement patterns agree by design. Thus, the measurement patterns for the collection of virtual sub-regions combine to form a pattern on the whole modulating array.