Invention Grant
- Patent Title: Substituted naphthyridines and their use as medicaments
- Patent Title (中): 取代的萘啶并用作药物
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Application No.: US13013973Application Date: 2011-01-26
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Publication No.: US08969568B2Publication Date: 2015-03-03
- Inventor: Matthias Hoffmann , Georg Dahmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
- Applicant: Matthias Hoffmann , Georg Dahmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
- Current Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Usha R. Patel
- Priority: EP10152159 20100129
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D471/04 ; C07D519/00

Abstract:
The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.
Public/Granted literature
- US20120028939A1 SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS MEDICAMENTS Public/Granted day:2012-02-02
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