Invention Grant
- Patent Title: Bioactive implant for myocardial regeneration and ventricular chamber restoration
- Patent Title (中): 生物活性植入物用于心肌再生和心室恢复
-
Application No.: US13660086Application Date: 2012-10-25
-
Publication No.: US08968417B2Publication Date: 2015-03-03
- Inventor: Juan Carlos Chachques , Antonio Bayes Genis , Manuel Monleon Pradas , Carlos Eduardo Semino , Nicole Zur Nieden , Philippe Jenny
- Applicant: Creaspine
- Applicant Address: ES Bacelona ES Valencia ES Barcelona FR Paris
- Assignee: Institut Quimic de Sarria,Universitad Politecnica de Valencia,Fundacio Institut d'Investigacio Sanitaria Germans Trias Pujol,Association Cardio-Monde
- Current Assignee: Institut Quimic de Sarria,Universitad Politecnica de Valencia,Fundacio Institut d'Investigacio Sanitaria Germans Trias Pujol,Association Cardio-Monde
- Current Assignee Address: ES Bacelona ES Valencia ES Barcelona FR Paris
- Agency: Porzio, Bromberg & Newman, P.C.
- Priority: EP10305851 20100730
- Main IPC: A61F2/24
- IPC: A61F2/24 ; A61F13/00 ; A61F2/00 ; A61L27/26 ; A61L27/38 ; A61L27/52 ; A61L27/54 ; A61L27/56

Abstract:
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restauration of the heart conical shape. Cardiac wrapping by ventricular support bioprostheses of the present invention, having reinforcement bands spatially distributed as helicoids, recovers the sequential contraction of the myocardium resulting in the successive shortening and lengthening of the ventricles, therefore improving the ejection (systolic function) and suction of blood (diastolic function).
Public/Granted literature
- US20130116789A1 BIOACTIVE IMPLANT FOR MYOCARDIAL REGENERATION AND VENTRICULAR CHAMBER RESTORATION Public/Granted day:2013-05-09
Information query
IPC分类: