Methods, systems, and apparatus, including computer program products, for identifying regions of interest in an image and identifying a barcode in a degraded image are provided. A region of interest is identified by pre-processing an image, generating a binary image based on a metric calculated on the pre-processed image, and analyzing regions of the image identified using connected components and other analysis. A barcode is identified by searching a population of barcodes, degrading ideal image intensity profiles of candidate barcodes, and comparing the degraded ideal image intensity profiles to an image intensity profile of the degraded image.