Invention Grant
- Patent Title: Process for the preparation of amino acid derivatives
- Patent Title (中): 制备氨基酸衍生物的方法
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Application No.: US13127555Application Date: 2009-11-06
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Publication No.: US08946476B2Publication Date: 2015-02-03
- Inventor: Didier Bouvy , Alain Merschaert , Véronique Pinilla , Joerg Hamann , Ralf Kanzler , Antoine Thomas
- Applicant: Didier Bouvy , Alain Merschaert , Véronique Pinilla , Joerg Hamann , Ralf Kanzler , Antoine Thomas
- Applicant Address: DE Monheim
- Assignee: UCB Pharma GmbH
- Current Assignee: UCB Pharma GmbH
- Current Assignee Address: DE Monheim
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: EP08105749 20081107
- International Application: PCT/EP2009/007962 WO 20091106
- International Announcement: WO2010/052011 WO 20100514
- Main IPC: C07C231/20
- IPC: C07C231/20 ; C07C237/22 ; C07C231/18
Abstract:
The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).
Public/Granted literature
- US20110263899A1 Novel Process for the Preparation of Amino Acid Derivatives Public/Granted day:2011-10-27
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