Invention Grant
US08946244B2 2′-fluoro-6′methylene carbocyclic nucleosides and methods of treating viral infections
有权
2'-氟-6'-亚甲基碳环核苷和治疗病毒感染的方法
- Patent Title: 2′-fluoro-6′methylene carbocyclic nucleosides and methods of treating viral infections
- Patent Title (中): 2'-氟-6'-亚甲基碳环核苷和治疗病毒感染的方法
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Application No.: US13510090Application Date: 2010-11-16
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Publication No.: US08946244B2Publication Date: 2015-02-03
- Inventor: Chung K. Chu , Jianing Wang
- Applicant: Chung K. Chu , Jianing Wang
- Applicant Address: US GA Athens
- Assignee: University of Georgia Research Foundation, Inc.
- Current Assignee: University of Georgia Research Foundation, Inc.
- Current Assignee Address: US GA Athens
- Agent Henry D. Coleman; R. Neil Sudol
- International Application: PCT/US2010/056808 WO 20101116
- International Announcement: WO2011/060408 WO 20110519
- Main IPC: A61K31/52
- IPC: A61K31/52 ; A61K31/675 ; A61K31/7068 ; C07D473/34 ; C07F9/24 ; A61K45/06
Abstract:
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Hepatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses.
Public/Granted literature
- US20130005677A1 2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS Public/Granted day:2013-01-03
Information query
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