Invention Grant
US08946233B2 Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
有权
双作用噻吩，吡咯，噻唑和呋喃抗高血压药
- Patent Title: Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
- Patent Title (中): 双作用噻吩，吡咯，噻唑和呋喃抗高血压药
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Application No.: US14157151Application Date: 2014-01-16
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Publication No.: US08946233B2Publication Date: 2015-02-03
- Inventor: Paul R. Fatheree , Robert Murray McKinnell
- Applicant: Paul R. Fatheree , Robert Murray McKinnell
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/427
- IPC: A61K31/427 ; A61K31/497 ; A61K31/506 ; A61K31/4427 ; C07D277/56 ; C07D401/04 ; C07D401/14 ; C07D207/34 ; C07D401/06 ; C07D403/10 ; C07D413/10 ; C07D401/10 ; C07D417/06 ; C07D417/10 ; C07D417/14
Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20140135333A1 DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS Public/Granted day:2014-05-15
Information query
IPC分类:
