Invention Grant
US08945848B2 Methods and compositions for identifying and validating modulators of cell fate
有权
用于鉴定和验证细胞命运调节剂的方法和组合物
- Patent Title: Methods and compositions for identifying and validating modulators of cell fate
- Patent Title (中): 用于鉴定和验证细胞命运调节剂的方法和组合物
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Application No.: US13387962Application Date: 2010-07-30
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Publication No.: US08945848B2Publication Date: 2015-02-03
- Inventor: Kambiz Shekdar , Dennis J. Sawchuk , Jessica C. Langer
- Applicant: Kambiz Shekdar , Dennis J. Sawchuk , Jessica C. Langer
- Applicant Address: US NJ North Brunswick
- Assignee: Chromocell Corporation
- Current Assignee: Chromocell Corporation
- Current Assignee Address: US NJ North Brunswick
- Agency: Jones Day
- International Application: PCT/US2010/043852 WO 20100730
- International Announcement: WO2011/014740 WO 20110203
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/50 ; C07H21/00 ; C07H21/02 ; C07H21/04 ; C12N15/00
Abstract:
The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs. The invention relates to methods for making cells comprising one or more reporter nucleic acid constructs using fluorogenic oligonucleotides. The methods relate to high throughput screens.
Public/Granted literature
- US20120276572A1 METHODS AND COMPOSITIONS FOR IDENTIFYING AND VALIDATING MODULATORS OF CELL FATE Public/Granted day:2012-11-01
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