A surgical manipulation instrument which is particularly suitable for minimal invasive surgery, comprising an extra-corporeal drive device and a partial intra-corporeal manipulator part. The drive device comprises several axially displaceable first actuation elements. The first actuation elements are detachably connected to axially displaceable second actuation elements, by a coupling device, the second actuation elements being used to actuate an end effector. The coupling device comprises two coupling elements, one of the coupling elements having undercut recesses in which the second coupling element engages.