The present invention provides a pneumatic tire for a motorcycle which secures a sufficiently large lateral force in the intermediate region contacting the ground particularly when a middle camber angle is applied to the tire and increases a driving force and a braking force. The tire comprises a tread portion 1, side wall portions 2 and bead portions 3. This tread portion 1 comprises five regions of a central region A, shoulder regions C and intermediate regions B. Loss tangent of at least a portion forming a ground contact surface of an intermediate tread rubber 7b disposed over an entire region of the intermediate regions B is larger than both of loss tangent of at least a portion forming a ground contact surface of a central tread rubber 7a disposed over an entire region of the central region A and loss tangent of at least a portion forming a ground contact surface of a shoulder tread rubber 7c disposed over an entire region of the shoulder regions C.