Circuits and methods are provided for detecting, identifying and/or removing undesired content. According to one embodiment, a method for virus processing content objects is provided. A content object is stored within a system memory by a general purpose processor using a virtual address. Most recently used entries of a page directory and a page table of the system memory are cached within a translation lookaside buffer (TLB) of a virus co-processor. Instructions are read from a virus signature memory of the co-processor. Those of a first type are assigned to a first of multiple instruction pipes of the co-processor. The first instruction pipe executes an instruction including accessing a portion of the content object by performing direct virtual memory addressing of the system memory using a physical address derived based on the virtual address and the TLB and comparing it to a string associated with the instruction.