In a microprocessor that has an instruction set architecture in which the instructions may include a variable number of prefix bytes, an apparatus for efficiently extracting instructions from a stream of undifferentiated instruction bytes. Decode logic determines which byte is an opcode byte for each instruction of a plurality of instructions within the stream of undifferentiated instruction bytes. The opcode byte is the first non-prefix byte of the instruction. The decode logic accumulates prefix information onto the opcode byte of the instruction for each instruction of the plurality of instructions. A queue holds the stream of undifferentiated instruction bytes and the accumulated prefix information. Extraction logic extracts the plurality of instructions from the queue in one clock cycle independent of the number of prefix bytes included in each of the plurality of instructions.