An earphone jack drive circuit applied in an electronic device is provided. The earphone jack drive circuit includes a mute circuit; a micro-controller including a detect pin and a control pin; a delay switch circuit including a resistance, a capacitance, an npn transistor and a first current-limiting resistance. During the plugging in or the unplugging out of the earphone, any momentary logic high of the detect pin charges the capacitance, the capacitance discharges when the detect pin is set to be logic low. For a period, the npn transistor is kept on, the connector of the npn transistor is set to be logic low, the input port of the mute circuit is set to be logic low, thereby the mute circuit is controlled to perform the mute mode during the period to eliminate the popping noises of connection and disconnection.