An electrostatic discharge (ESD) protection device is disclosed. The ESD protection circuit is configured to operate in high voltage domains. The ESD protection device may further include stacked NMOS or PMOS devices. The gates of the MOS devices may be driven by respective inverters. The inverters may be coupled to a voltage divider and may be triggered by respective trigger circuits. Power nodes of the inverters may be connected such that devices in the ESD protection circuit are exposed to voltages that are within their maximum voltage rating.