A multi-color electrophoretic display (EPD) device, an image sheet, and a method of manufacturing the same. The method of manufacturing the multi-color EPD device includes: forming capsules including photosensitive color-developing capsule shells each of which stores a dielectric fluid and at least one type of electrophoretic particles dispersed in the dielectric fluid; disposing the capsules in a unit color pixel area on a substrate; exposing the capsules to light to form a latent image of a color pattern image on the capsules; and developing the photosensitive color-developing capsule shells of the capsules to form unit color pixels including color capsules.